Jurnal Farmasi Dan
Ilmu Kefarmasian Indonesia Vol. 4 No. 1
Juli 2017
1
P
-
ISSN:
2406
-
9388
E
-
ISSN: 2580
-
8303
Efek Serbuk Bunga Rosella Merah
(
H
ibiscus
sabdariffa
L
.)
t
erhadap Ekspresi IL
-
10
p
ada Sukarelawan Sehat
Nur Azizah
Syahrana
1
*
,
Akrom
1
,2
,
E
ndang Darmawan
1
1
Pascasarjana
Fakultas
Fa
rmasi
,
Universitas
Ahmad Dahlan,
Yogyakarta
2
Pusat informasi dan kajian obat
,
Universitas Ahmad Dahlan,
Yogyakarta
*Corresponding author
:
nurazizah.syahrana19@gmail.com
Abstract
Background
:
Rose
lla calyx (Hibiscus sabdariffa
L
.) contain phenol and anthocyanin flavonoids that
have
activity as antioxidants and can
stimulate
the immune system.
Objective
:
The purpose of this study was to
investigate the effect of rosella powder capsule on expression IL
-
10 using pre and post test method on 21 healthy
volunteers who fulfilled inclus
ion criteria and willing to fill informed consent.
Method
s
:
Volunteers were given
rosella powder in capsules form with 500 mg dose for 30 days and IL
-
10 was examined using
flowsitometric
method on days 0.
30 and 45. The results were analyzed using SPSS with
wilcoxon test.
Result
s
: The valu
e of IL
-
10 expression in the 0.
30 and 45 day volunteers were 0.42 ± 0.24; 0.83 ± 0.47 and 1.06 ± 0.67. These results
showed that IL
-
10 expression had an effect on day 0 to 30 (p <
0.05) and IL
-
10 expression did not affec
t t
he
30 day of the 45 (p
> 0.05)
.
Conclusion
: administration of rosella powder capsules (Hibiscus sabdariffa L.) dose
500 mg/day for 30 days increased the expression of IL
-
10, but within normal limits on healthy volunteers
.
K
eywords
:
r
oselle
, IL
-
10
e
xpr
ession
,
h
ealthy
v
olunteers